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-synuclein, which happens to be a key component of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) stress, propose that dysfunction in the intracellular proteinase devices, such as ubiquitin-proteasome technique or lysosomal procedure, which gets rid of avoida
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